Composition: Enoxaparin Sodium
Strengths: 60mg, 40mg
Dosage From: Pre-filled syringe.
Mechanism of Action: Enoxaparin is a type of low molecule weight heparin (LMWHs) with a mean molecule weight of 4000 to 5000. It has an immediate onset of action when given in the intravenous form. It binds to and potentiates anti-thrombin III, a serine protease inhibitor, to form a complex that irreversibly inactivates factor Xa. Enoxaparin has less activity against factor IIa (thrombin) compared to unfractionated heparin.
Indications:
Dosage:1mg of Enoxaparin is equal to 100 units of anti–Xa activity. The usual dose is 1milligram/kilogram every 12 hr. However, dosing can be variable depending on the clinical situation. Treatment of Deep Vein Thrombosis with or without Pulmonary Embolism: In outpatient treatment, patients with acute Deep Vein Thrombosis without pulmonary embolism who can be treated at home, the recommended dose of Enoxaparin is 1mg/kg every 12 hours administered SC.
Advantage:Advantage over unfractioned Heparin is that no monitoring is required.